Abstract
The search for the mechanisms underpinning chemotherapy-induced metastasis is an urgent one since metastatic disease is the main cause of cancer related mortality. We recently showed that Doxorubicin and Daunorubicin, commonly used anticancer drugs, increase cell stiffness before causing cell death, predisposing the cells to clogging and extravasation, the latter being a step in metastasis. Several lines of compelling pre-clinical evidence by other groups following our findings have reported that well known anticancer drugs with therapeutic efficacy on the primary tumor also induce tumor/host reactive responses supportive of dissemination of cancer cell subpopulations.
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