Abstract
Abstract The leishmaniases are a group of diseases that affect millions of people worldwide. In the present study, we investigated the participation of CD8+ T cells during infection with L. braziliensis, the main etiolological agent of mucocutaneous leishmaniasis. Following inoculation of L. braziliensis into the ear dermis of BALB/c mice, we observed a high proportion of CD8+CD25+, at the time of lesion appearance, whereas CD8+CD69+ T cells were found at a greater proportion in the draining lymph nodes, at this same time point. Regarding cytokine production, a high percentage of CD8+IFN-g+ cells was detected as early as two weeks post infection, at the ear dermis. The same kinetics was observed for expression of CD107b. Interestingly, presence of IL-4+ and IL-10+ T cells was also detected during the course of infection in the ear dermis. Parasite load in β2-m deficient mice was smaller than in wild type (WT) mice. However, transfer of CD8+ cells obtained from L. braziliensis-primed mice induced the control of lesion development upon transfer to infected mice. These data indicate that CD8+ T cells may play a protective role in cutaneous leishmaniasis caused by L. braziliensis.
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