Abstract
Background Eosinophils play a key role in allergic diseases such as bronchial asthma and atopic dermatitis. A prominent feature of these diseases is the accumulation of eosinophils in inflamed tissue induced by several chemoattractants like prostaglandin (PG) D2 or eotaxins. After the discovery of the endocannabinoid system and investigation of several endogenous and synthetic ligands, evidence has accumulated that cannabinoids, especially CB2 receptor ligands, may play a major role in mediating inflammatory responses. Elevated levels of 2-arachidonoylglycerol (2AG; a CB1/CB2 agonist) were found in tissues of mouse models of allergic inflammation, suggesting a possible involvement in leukocyte recruitment.
Highlights
Eosinophils play a key role in allergic diseases such as bronchial asthma and atopic dermatitis
We found that CB2 receptor agonists like the endocannabinoid 2-AG or the synthetic selective agonist JWH-133 significantly increased eosinophil responses in shape change assays induced by PGD2 or eotaxin-1
As cytoskeletal changes are required for firm arrest and leukocyte diapedesis, transmigration assays were conducted subsequently, confirming the shape change data as eosinophil migration induced by PGD2 was increased by pretreatment with JWH-133
Summary
Eosinophils play a key role in allergic diseases such as bronchial asthma and atopic dermatitis. A prominent feature of these diseases is the accumulation of eosinophils in inflamed tissue induced by several chemoattractants like prostaglandin (PG) D2 or eotaxins. After the discovery of the endocannabinoid system and investigation of several endogenous and synthetic ligands, evidence has accumulated that cannabinoids, especially CB2 receptor ligands, may play a major role in mediating inflammatory responses. Elevated levels of 2-arachidonoylglycerol (2AG; a CB1/CB2 agonist) were found in tissues of mouse models of allergic inflammation, suggesting a possible involvement in leukocyte recruitment
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