The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers.

Cheng-Di Wang,Jing-Wen Huang,Ting Wang,Yu-Lin Ji,Min Zhu,Lin Huang,Nan Chen,Yan Sun

doi:10.1038/srep26973

Cheng-Di Wang, Jing-Wen Huang + Show 6 more

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https://doi.org/10.1038/srep26973

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Abstract

Catalase (CAT), one antioxidant enzyme, may provide resistance against many diseases. Many previous studies reported predictive and prognostic values of CAT C262T polymorphism in cancers, with divergent results. This study aimed to summarize the overall relationships between CAT C262T polymorphism and cancer risk or survival. A total of 27 eligible publications were included in susceptibility analysis, while 8 publications contained survival outcomes. The results revealed significant relationship between CAT C262T polymorphism and cancer risk(TT + CT vs CC: OR = 1.05, 95%CI = 1.00–1.10, P = 0.036), subgroup analyses indicated the CAT C262T polymorphism was significantly correlated with an increased risk for prostate cancer (TT vs CC + CT: OR = 1.43, 95%CI = 1.20–1.70, P < 0.001) and increased risk among Caucasians (TT vs CC + CT: OR = 1.19, 95%CI = 1.09–1.31, P < 0.001), while no associations between the polymorphism and Asian or mixed population were established. In the survival analysis, no interactions were identified between this polymorphism and cancer survival (TT + CT vs CC: HR = 1.37, 95%CI = 0.70–2.70, P = 0.36). In conclusion, the CAT C262T polymorphismmay be a candidate markerfor cancer risk with type-specific and population-specific effects but not a fine prognostic factor for cancer survival.

Highlights

The molecular mechanisms of carcinogenesis have not been wellunderstood, but growing studies have reported that oxidative stress played a significant role in the progression of many diseases, including cancers[1]
In terms of subgroup analysis by ethnicity (Caucasian, Asian and Mixed), the assessment of the results revealed that the CAT C262T polymorphism was associated with cancer risk in Caucasians (TT vs CT +CC: odds ratios (ORs) = 1.19, 95% confidence intervals (95%CIs) = 1.09–1.31 P < 0.001; TT vs CC: OR = 1.24, 95%CI = 1.12–1.38, P < 0.001; T vs C: OR = 1.08, 95%CI = 1.01–1.16, P = 0.02)
CAT belongs to the antioxidant molecules and is present in all aerobic cells while the highest levels of the enzyme are found in the liver, kidneyand erythrocytes[44]

Summary

Introduction

The molecular mechanisms of carcinogenesis have not been wellunderstood, but growing studies have reported that oxidative stress played a significant role in the progression of many diseases, including cancers[1]. Antioxidant defense system could prevent or combat the negative effects caused by ROS, including myeloperoxidase (MPO), glutathione peroxidase (GPX), catalase (CAT), and mitochondrial manganese superoxide dismutase (MnSOD)[6,7,8]. In comparison with the variant C allele, the variant T allele of the CAT C262T polymorphism has been reported to indicate lower enzyme activity, raising the levels of ROS and might lead to cancer development or progression[14]. Some studies have indicated the CAT C262T polymorphismcould increase prostate cancer risk[6,16,18]. No studies confirmed whether the CAT C262T polymorphism could be a prognostic factor of cancer patients. We conducted this updated meta-analysis to comprehensively estimate the relationships between the CAT C262T polymorphism and susceptibility or survival of cancers

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