Abstract
Caspases are key mediators of apoptosis. Caspase-8 mediates extrinsic, and caspase-9 initiates the intrinsic pathway of apoptosis. Apoptosis Inducing Factor (AIF), a mitochondrial proapoptotic protein, mediates cell death by a caspase-independent process. Because apoptosis is involved in periodontal disease, this study evaluated caspase-8, -9, and AIF in periodontal disease. Twenty periodontally healthy volunteers (Group Healthy), 20 patients with generalized aggressive periodontitis (Group AgP), and 20 patients with generalized chronic periodontitis (Group CP) were included in this study. Levels of caspase-8, -9, and AIF were evaluated in gingival crevicular fluid (GCF) of all participants via enzyme-linked immunosorbent assays. AIF was significantly higher in the AgP (P=0.07) and CP groups (P=0.01) than the Healthy group, and similar to the CP and AgP groups (P>0.05). Caspase-8 was significantly higher in the CP and Healthy groups than the AgP group (P=0.00), and similar between Healthy and CP groups (P>0.05). Caspase-9 was significantly higher in the AgP group than the Healthy group (P=0.01), and similar between Healthy and CP groups (P>0.05). The mitochondrial-centered intrinsic pathway involving caspase-9 and AIF, and the extrinsic pathway involving caspase-8 are significant for aggressive periodontitis. The intrinsic pathway involving caspase-independent AIF is also significant for chronic periodontitis.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
