Abstract
In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis.
Highlights
Reviewed by: Katsuhito Fujiu, The University of Tokyo, Japan Emiliano Medei, Federal University of Rio de Janeiro, Brazil Justin Deniset, University of Calgary, Canada
Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs)
A recent study published in Cell demonstrated that resident macrophages in the steady-state heart facilitated electrical conduction, highlighting a novel concept regarding the potential role of cardiac macrophages in modulating cardiac electrical function (Hulsmans et al, 2017)
Summary
Mingxian Chen1†, Xuping Li1†, Songyun Wang, Lilei Yu2, Jianjun Tang1* and Shenghua Zhou1*. Reviewed by: Katsuhito Fujiu, The University of Tokyo, Japan Emiliano Medei, Federal University of Rio de Janeiro, Brazil Justin Deniset, University of Calgary, Canada. Specialty section: This article was submitted to Cardiac Electrophysiology, a section of the journal Frontiers in Physiology. Cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis
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