THE ROLE OF CANNABIDIOL IN THE INFLAMMATORY PROCESS AND ITS PROPERTIES AS AN ALTERNATIVE THERAPY – A REVIEW (META-ANALYSIS)

Abstract

Abstract
 Cannabis has been used as a medicinal plant for thousands of years in Asia. Numerous physical, psychological, and emotional benefits have been attributed to cannabis since its first reported use in 2,600 BC in a Chinese pharmacopoeia. Recent years have seen a resurgence in interest in the therapeutic potential of compounds derived from these plants, mainly the non-psychoactive compound cannabidiol (CBD). In this way, we seek to evaluate, through this present study, what has been published about CBD in the Pubmed / Medline database in the last two years (2019/2020) in relation to anxiety, depression, panic attack and dementia, as well as therapeutic dosages, results with significant values, side effects and others reported in the studies found. The results were distributed in 4 tables. In the first, the types of publication were reported; in the second, the proposal for evaluation; in the third, the results with significance evaluated; and in the fourth the doses used. Although the majority of studies found are in the form of a review (55.3%), several studies in humans have shown promising results with the use of CBD in therapies. The treatments for anxiety and stress with CBD were the most evident accounting for 37.8% of the total studies found in table 2. The relationship of CBD in metabolic processes as inflammatory markers, activator of specific nuclear receptors and protein modulations was the second most evident item na tabela 2 with 11,1%. Cognitive processes and depression appear comes in sequence with 8.9% both. The results of significance values found in this study demonstrated a good acceptance in the treatment with CBD regarding anxiety and stress. With 70.6% of positive results in table 3, CBD appears as a promising option in the treatment of anxiety, stress and similar behaviors. Regarding depression, the results were slightly lower. With 66.6% positive results, depression can also be treated with CBD as an alternative therapy option. In dose used CBD administration are extremely diverse. The doses ranged from 25mg to 800mg depending on the time of administration and also the purpose of the therapy. Although the results presented in this study are promising, we need more information to be able to position ourselves on the efficiency of CBD in proposed treatments.