Abstract
1. 1. Noradrenaline hyperpolarizes frog sartorius muscle fibres. Ouabain prevents this hyperpolarization, which is likely due to activation of an electrogenic sodium pump. 2. 2. Decreases or increases in the normal calcium content of the perfusion solution can cause a reduction in the magnitude of noradrenaline-elicited hyperpolarization and reduce its sensitivity to ouabain. 3. 3. In the presence of 0 mM Ca 2+ and 5 mM EDTA, noradrenaline failed to hyperpolarize the muscle fibres. 4. 4. The results suggest that calcium ions are essential for noradrenaline-elicited activation of the ouabin-sensitive electrogenic pump. The pump may be inhibited by excessive levels of calcium in the perfusion solution.
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