Abstract
Calcium deprivation inhibits the formation and subsequent release of SRS-A as well as histamine from passively sensitized human lung fragments challenged with antigen. Antimycin A inhibits the release of histamine and SRS-A in a dose dependant fashion, while causing a mild inhibition of SRS-A formation throughout the dose range studied. These data suggest that the influx of calcium is the critical event for the generation of SRS-A within the cell.
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