Abstract
Background: Chronic kidney disease is an end stage leads to problems in bone as rheumatoid arthritis (RA) with both glomerular and tubular damage. It is often difficult to differentiate between damage due to disease activity and that due to drugs used to treat Rheumatoid Arthritis.
 The aim: To estimate the levels of Calcitonin and Vitamin D and their relationship with renal Osteodystrophy
 Methods: Calcitonin and Vitamin D were obtained from 135samples: 85 samples from patients with chronic renal failure, 25 samples with (CRF with arthritis) renal Osteodystrophy, and 25 samples apparently healthy .
 Results: A highly significant increase (p<0. 001) in the level of calcitonin in serum of patients with Chronic renal failure and renal osteodystrophy disease compared with healthy individuals. Highly significant decrease (p<0. 001) in the level of vitamin D in serum of patients with chronic renal failure and renal osteodystrophy disease compared with healthy individuals.
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