Abstract
Redox homeostasis is regulated by critical molecules that modulate antioxidant and redox signaling (ARS) within the cell. Imbalances among these molecules can lead to oxidative stress and damage to cell functions, causing a variety of diseases. Brahma-related gene 1 (BRG1), also known as SMARCA4, is the central ATPase catalytic subunit of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, which plays a core role in DNA replication, repair, recombination, and transcriptional regulation. Numerous recent studies show that BRG1 is involved in the regulation of various cellular processes associated with ARS. BRG1, as a major factor in chromatin remodeling, is essential for the repair of oxidative stress-induced DNA damage and the activation of antioxidant genes under oxidative stress. Consequently, a comprehensive understanding of the roles of BRG1 in redox homeostasis is crucial to understand the normal functioning as well as pathological mechanisms. In this review, we summarized and discussed the role of BRG1 in the regulation of ARS.
Highlights
Brahma-related gene 1 (BRG1), known as SMARCA4, is the central catalytic ATPase of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, which alters the structure of reconstituted chromatin particles in an ATP-dependent manner and makes genomic regions more accessible to transcription factors and the transcription machinery [1]
BRG1 plays an important role in redox regulation and regulating cellular homeostasis by establishing specific gene expression patterns and maintaining the transcriptional state
The maintenance of redox homeostasis is required for various feedback mechanisms, mainly related to transcriptional modulation, to function at different levels
Summary
Brahma-related gene 1 (BRG1), known as SMARCA4, is the central catalytic ATPase of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, which alters the structure of reconstituted chromatin particles in an ATP-dependent manner and makes genomic regions more accessible to transcription factors and the transcription machinery [1]. This study found that oxidative stress-induced BRG1 could bind to the promoter of the antioxidant defense gene and induce its transcription, protecting cells from oxidative damage. HIF1α, HIF2α, and many other key metabolic regulators are major regulators of survival pathways activated by various cellular stresses (such as hypoxia) [17, 18]; it is reasonable to assume that BRG1 plays a key role in regulating oxidative stress. Oxidative Medicine and Cellular Longevity overexpression mitigated hypoxia-induced cell damage, while BRG1 suppression contributed to hypoxia-induced cell damage [19]. Taken together, these studies suggest that BRG1 is involved in oxidative stress and may have an antioxidant effect
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
