Abstract
The kinins are pharmacologically active polypeptides, which are released in the tissues and body fluids as a result if the enzymatic action of kallikreins on kininogens. The kinin family includes BK (Arg-ProPro-gly-Phe-Ser-Pro-Phe-Arg), kallidin (Lys-Arg-Pro-Pro-Gly-PheSer-Pro-Phe-Arg) and methionyl-lysyl-BK (Met-Lys-Arg-Pro-ProGly-Phe-Arg). Kallidin and methionyl-lysyl-BK are converted into BK by aminopeptidases present in plasma and urine [1]. Kinins are rapidly (<15 sec) inactivated by circulating kininases [2].
Highlights
The kinins are pharmacologically active polypeptides, which are released in the tissues and body fluids as a result if the enzymatic action of kallikreins on kininogens
Active tissue kallikrein acts on Low Molecular Weight Kininogen (LMWK) to release kallidin
Bradykinin (BK), a pharmacologically active polypeptide, is one of kinins which is released in the tissues and body fluids as a result of enzymatic action of kallikreins on kininogens
Summary
The kinins are pharmacologically active polypeptides, which are released in the tissues and body fluids as a result if the enzymatic action of kallikreins on kininogens. The plasma kallikrein is found in circulation in an inactive form, which is known as prekallikrein or Fletcher factor [11]. Previous studies have indicated altered activities of the bradykinin-forming components [19] in diabetic patients and experimental animals.
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