Abstract
Summary: Bone morphogenetic proteins are multi-functional molecules that play an important role in tissue differentiation. The classic BMPs (BMP-2, 4, 7) are osteoinductive, whereas more recently described BMPs (BMP-12, 13) are expressed during tendon insertion site formation in embryogenesis and have been found to induce formation of fibrocartilage. This review examines several studies that have tested the effects of bone morphogenetic proteins in rotator cuff tendon repair models.
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