Abstract
AbstractIntravenous administration to cats of a barium sulphate suspension caused a temporary and marked increase in the pulmonary vascular resistance. On repeated infusions there was a gradual decrease in this pulmonary response. At the same time there occurred a marked fall in the number of circulating blood platelets. Another group of cats were made thrombocytopenic beforehand by treatment with anti‐platelet serum In such cats infusions of barium sulphate gave no or very weak pulmonary vascular response. The presence of a certain number of circulating blood platelets is thus necessary for barium sulphate infusions to have their marked effects on the pulmonary circulation. It appears that the essential effect of barium sulphate in this connection is to cause blood platelet alterations, with aggregation and probably a subseqent release of vasoactive materials.
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