Abstract
Currently, due to the dynamic development of surgical technologies, indications for organ-sparing treatment of kidney cancer are expanding. Acute kidney injury is a serious complication that leads to chronic kidney disease, increased postoperative mortality, deterioration of long-term functional outcomes, and increased hospitalization. At present, it is known that even a slight damage to kidneys or their impairment, presented by a decreased urine output and change in blood biochemical parameters, entails serious clinical consequences and is associated with a poor prognosis. Damaging factors, when the kidney is exposed, initially induce molecular changes, which entail the production of certain biomarkers, and only after that clinical aspects of kidney damage develop. The causes of acute kidney injury can be different, from specific renal disorders (acute interstitial nephritis, vascular and glomerular lesions, prerenal azotemia, obstructive disorders) to toxic damages, direct trauma and surgical treatment. The development of acute renal injury in the postoperative period is a serious complication of the surgical treatment of kidney disease, and, according to various authors, the frequency of its occurrence varies from 5.5 % to 34 %. An active study of this problem made it possible to find specific biomarkers that give the possibility to predict and diagnose acute renal injury in the early stages, to optimize the treatment strategy, to reduce the incidence of postoperative complications, and to shorten the period of postoperative rehabilitation. Currently, the most studied of acute kidney injury (AKI) biomarkers are cystatin C, neutrophil gelatinase-associated lipocalin‑2 (NGAL), hepatic protein L-FABP, KIM‑1 (Kidney injury molecule‑1), Interleukin – 18. Further study of AKI biomarkers will make it possible to determine the most significant ones for subsequent use in everyday practice
Highlights
Острое повреждение почек (ОПП) – это синдром, характеризующийся стадийным нарастанием острого почечного поражения от умеренных изменений почечной функции вплоть до полной ее утраты
В исследовании с помощью разработанной персонифицированной шкалы ранней диагностики ОПП было выявлено 15 пациентов с преклиничекой формой ОПП, 6 пациентам после проведения резекции почки был проведен лечебный плазмаферез
В исследовании с помощью разработанной персонифицированной шкалы ранней диагностики Острое повреждение почек (ОПП) (основанной на концентрации цистатина-С , L-FABP и neutrophil gelatinase-associated lipocalin‐2 (NGAL)) было выявлено 15 пациентов с преклиничекой формой ОПП, 6 пациентам после проведения резекции почки был проведен лечебный плазмаферез
Summary
Острое повреждение почек (ОПП) – это синдром, характеризующийся стадийным нарастанием острого почечного поражения от умеренных изменений почечной функции вплоть до полной ее утраты. 97-107 И.О.Дементьев*, К.М.Нюшко, О.Б.Карякин, В.С.Чайков, А.В.Троянов, И.Н.Заборский, Е.О.Щукина / Роль биомаркеров острого повреждения почек в прогнозировании функциональных результатов хирургического лечения у больных локализованным раком почки
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
