Abstract
The characteristic chemical fragments named as functional reactive groups (or descriptors) in the molecules of biologically active substances (BASs) are described. These fragments are characterized by the presence of an active hydrogen atom or unsaturated function. It is concluded that BASs are essential factors working in concert with gene keys and gene locks to starts transcription. The gene keys are nucleic acids but not proteins. It is postulated that cell membrane can serve as depot for gene keys at the beginning of oxidative stress. During the recession phase of oxidative stress new gene keys are synthesized for new transcription acts.
 Keywords: BASs, descriptors, gene keys, gene locks, transcription.
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