Abstract
The neuroimmune system plays a crucial role in the regulation of mood disorders. Moreover, recent studies show that brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is a key regulator in the neuroimmune axis. However, the potential mechanism of BDNF action in the neuroimmune axis' regulation of mood disorders remains unclear. Therefore, in this review, we focus on the recent progress of BDNF in influencing mood disorders, by participating in alterations of the neuroimmune axis. This may provide evidence for future studies in this field.
Highlights
Mood disorders are one of the most common mental disorders in the world, especially in western society
brain-derived neurotrophic factor (BDNF) could promote the regeneration of 5-HT neurons in the central nervous system (CNS), so the large consumption of 5-HT in the CNS reduces the BDNF level, which leads to the atrophy and death of nerve cells, affects neural plasticity, and aggravates depressive symptoms [34]
Freire et al found that neither the combined group, nor the pharmacological group resulted in the increase of the serum BDNF level in patients with depression, both significantly improved the depressive symptoms of patients [61]
Summary
Mood disorders are one of the most common mental disorders in the world, especially in western society. Mood disorders can be divided into four types: depressive episode, manic episode, bipolar disorder, and a persistent mood disorder. It brings severe mental pain to patients and leads to other diseases, such as heart disease and cerebrovascular diseases. Several studies have shown that BDNF may be indispensable to the neuroimmune regulation of mood disorders. BDNF and Mood Disorders the latest progress in the role of BDNF in the neuroimmune axis regulation of mood disorders. It may provide new ideas for the research and treatment of mood disorders in the future
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