Abstract
The role of autophagy in liver diseases: mechanisms and potential therapeutic targets.
Highlights
In this special issue, original research and review articles have focused on the role of autophagy in the pathogenesis of the above mentioned liver diseases, bringing new knowledge and suggesting modulation of autophagy as basis for possible treatments for these pathologies
nonalcoholic fatty liver disease (NAFLD) ranges from isolated steatosis to nonalcoholic steatohepatitis (NASH) and steatofibrosis, which sometimes leads to cirrhosis and to hepatocellular carcinoma (HCC)
The authors describe the role of autophagy in specific cells, including hepatocytes, macrophages, hepatic stellate cells (HSCs), and cancer cells and outline its role in the evolution of hepatic complications associated with obesity, from steatosis to HCC
Summary
Original research and review articles have focused on the role of autophagy in the pathogenesis of the above mentioned liver diseases, bringing new knowledge and suggesting modulation of autophagy as basis for possible treatments for these pathologies. Editorial The Role of Autophagy in Liver Diseases: Mechanisms and Potential Therapeutic Targets Autophagy seems to play an important role in normal liver physiology, and in the pathogenesis of liver diseases such as nonalcoholic and alcoholic fatty liver, druginduced liver injury, protein conformational liver diseases, viral hepatitis, fibrosis, aging, liver cancer, and liver ischemiareperfusion injury.
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