Abstract
AbstractDefective proteostasis is one of the hallmarks neurodegenerative diseases. Of the different components of the proteostasis network, we are interested in autophagy and its changes with age. We have previously shown that, out of the different autophagic pathways that co‐exist in all mammalian cells, macroautophagy is the first that declines with age in the retina, A crosstalk between macroautophagy and chaperone mediated autophagy (CMA) has been described whereby, in aged mice retinas, the decrease in macroautophagy correlates with increased CMA. Our working hypothesis is that in aged and degenerated retinal cells increase CMA to compensate for macroautophagy loss, in an attempt to maintain cell viability. Here, I will present our latest data showing how CMA upregulation can protect photoreceptor cells in retinitis pigmentosa models.
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