Abstract
Curcumin, a yellow pigment in turmeric, has been proven to induce tumor apoptosis and inhibit tumor proliferation. Aurora‐A, an oncoprotein, plays vital roles in centrosomal activity and chromosome segregation. Although both curcumin and Aurora‐A regulate cell cycle, the effect of curcumin on Aurora‐A has not been concerned. In this study, we observe that curcumin‐induced growth inhibition of human bladder T24 and breast MCF‐7 cancer cells was associated with suppression of Aurora‐A protein and thus kinase activity. Aurora‐A siRNA acted similar to curcumin, resulting in monopolar spindle, G2/M arrest, and cell division reduction. Ectopic Aurora‐A restored the curcumin effects. Of notes, the anticancer effect of curcumin was enhanced by Aurora‐A siRNA, producing additivity and synergism effects in cell division and monopolar phenotype, respectively. The discovery of curcumin‐induced inhibition of oncoprotein Aurora‐A supports the application of curcumin in cancer treatments.(Supported in part by the National Science Council, Taiwan, No. NSC 98‐2313‐B‐003‐002‐MY3; the Ministry of Economic Affairs, Taiwan, No. 99‐EC‐17‐A‐17‐S1‐152; and the National Taiwan Normal University, Taiwan, No. 99‐D and NTNU100‐D‐06).
Published Version
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