The role of arginase and ornithine decarboxylase activity changes in the pathogenesis of liver injury in patients with acute leukemia with concomitant obesity

Ганна Сергіївна Маслова ,І М Skrypnyk

doi:10.24061/2413-0737.xxiv.2.94.2020.45

Abstract

Objective – to investigate the role of arginase, ornithine decarboxylase (ODC) activity in the liver injury pathogenesis in patients with acute myeloid (AML) and acute lymphoblastic (ALL) leukemia with concomitant obesity.Materials and methods. We examined 40 patients with newly diagnosed acute leukemia, including 20 patients with AML (10 (50%) men / 10 (50%) women) and 20 patients with ALL (12 (60%) men / 8 (40%) women), aged 16-77 years. The indicators of complete and biochemical blood tests were analyzed. Arginase and ODC activity was measured in the blood serum.Study results. Liver injury in patients with AML and ALL was characterized by cytolytic and cholestatic syndromes development. Arginase activity in patients with AML 3.9-fold, and in patients with ALL – 1.8-fold exceeded normal ranges (p<0.05). ODC activity in patients with AML and ALL was 1.9-fold higher compared to normal values (р<0.05).Conclusions. Manifestation of AML and ALL is accompanied by increased activity of arginase and ODC, which is associated with biochemical liver tests violation.

Highlights

We examined 40 patients with newly diagnosed acute leukemia, including 20 patients with acute myeloid (AML) (10 (50%) men / 10 (50%) women) and 20 patients with acute lymphoblastic (ALL) (12 (60%) men / 8 (40%) women), aged 16-77 years
Arginase and ornithine decarboxylase (ODC) activity was measured in the blood serum
Manifestation of AML and ALL is accompanied by increased activity of arginase and ODC, which is associated with biochemical liver tests violation

Summary

Introduction

Стаття є фрагментом НДР кафедри внутрішньої медицини No1 Української медичної стоматологічної академії «Розробка методів профілактики та лікування медикаментозно-індукованих уражень внутрішніх органів». Мета – дослідити роль активності аргінази, орнітиндекарбоксилази (ОДК) у патогенезі уражень печінки у хворих на гостру мієлобластну (ГМЛ) і гостру лімфобластну (ГЛЛ) лейкемію із супутнім ожирінням. Objective – to investigate the role of arginase, ornithine decarboxylase (ODC) activity in the liver injury pathogenesis in patients with acute myeloid (AML) and acute lymphoblastic (ALL) leukemia with concomitant obesity.

Results

Conclusion