Abstract

The Role of Antibodies to Steroid Hormones and Chemical Carcinogen Benzo[A]Pyrene in Preterm Prelabour Rupture of Membranes

Highlights

  • Infants born too early are of public health concern since complications associated with preterm birth (PTB) are the leading cause of children’s mortality and a major cause of morbidity and disability [1,2]

  • Preterm prelabour rupture of membranes (PROM) occurs in 40% of all spontaneous preterm deliveries. [3,4,5,6]

  • It was evident that the level of Ig A to E2 was considerably higher in women of group I than of group II (p=0,002)

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Summary

Introduction

Infants born too early are of public health concern since complications associated with preterm birth (PTB) are the leading cause of children’s mortality and a major cause of morbidity and disability [1,2]. The proportion of PTB has no tendency to decrease and remains at the level of 5-10% varying from region to region in different countries. In recent years it has increased as the result of new reproductive technologies [7]. The question about the pathogenesis of preterm PROM in pregnancy is considered from different angles. The violation of the autoimmune tolerance to own tissues can lead to a number of problems of reproduction including complications during pregnancy, PTB, recurrent miscarriage, infertility and malformations in the fetus [8]. As for medical scientific literature, a strong increase of antibodies to steroid hormones results in adverse pregnancy outcomes [9,10]. Preterm prelabour rupture of membranes (PROM) occurs in 40% of all spontaneous preterm deliveries

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