Abstract
Detection of antiganglioside autoantibodies and their association with clinically defined subtypes implicate an autoimmune mechanism of peripheraland cranial nerve damage in peripheral neuropathies. Increased titer of antibodies that react with human peripheral nerve antigens have been reported in patients with motor neuropathy including Guillain-Barré syndrome,chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy and sensory motor neuropathy. This study represents review of the data related to increased titers of anti-glucoconjugate antibodies in different autoimmune neuropathies and their correlation with existence of structural homology between bacterial and glycoconjugated structures, as a basis for understanding the immune pathological response to glycoproteins and glycolipids present in the human peripheral nerve as target antigens in autoimmune neuropathies. Evaluation of presence and increased level of autoantibodies against peripheral nerve antigens could be an important parameter in laboratory evaluation, diagnosis and prognosis of autoimmune neuropathies and contribute in more efficient therapeutic approaches in treatment of these pathological conditions. Keywords: anti-glycoconjugate antibodies, anti-ganglioside antibodies, peripheral nerves, autoimmune neuropathies
Highlights
IntroductionLj. Suturkova with different pathological and clinical features including Guillian-Barré syndrome(GBS) and its variants (motor, sensory and Miller-Fisher syndrome (MFS)), chronic inflammatory demyelinating poliradiculoneuropathy (CIDP) and Multifocal motor neuropathy (MMN) (Dalakas, 2013)
Increased titer of antibodies that react with human peripheral nerve antigens have been reported in patients with motor neuropathy including Guillain-Barré syndrome,chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy and sensory motor neuropathy
Chronic inflammatory demielynating neuropathy (CIDP) is demyelinating autoimmune polyneuropathy which is characterized by the presence of number of different antibodies to the constituents of the peripheral nerve and presence of the antiganglioside antibodies in patient serum (Willison and Yuki, 2002)
Summary
Lj. Suturkova with different pathological and clinical features including Guillian-Barré syndrome(GBS) and its variants (motor, sensory and Miller-Fisher syndrome (MFS)), chronic inflammatory demyelinating poliradiculoneuropathy (CIDP) and Multifocal motor neuropathy (MMN) (Dalakas, 2013). Chronic inflammatory demielynating neuropathy (CIDP) is demyelinating autoimmune polyneuropathy which is characterized by the presence of number of different antibodies to the constituents of the peripheral nerve and presence of the antiganglioside antibodies in patient serum (Willison and Yuki, 2002). This review focuses on the correlation of the increased titers of anti-glucoconjugate antibodies in different autoimmune neuropathies and existence of structural homology between bacterial and glycoconjugated structures, as an important parameter for understanding the immune pathological response to glycoproteins and glycolipids present in the human peripheral nerve as target antigens in autoimmune neuropathies
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