Abstract
Diabetes mellitus exerts a sex-dependent effect on hepatic drug metabolism in the rat and it has been suggested that this is due to a reduction in serum androgen levels. This study shows that the effect of diabetes is only seen in the presence of androgen and that testosterone can reverse the effect of diabetes on drug metabolism. Diabetes, however, does not consistently cause a reduction in serum testosterone. Diabetes and androgens, therefore, are postulated to interact in their effects on drug metabolism by action on a common mediator. It is suggested that this mediator is growth hormone, which is known to be affected by the androgens and insulin and to be involved in sex differences in drug metabolism in the rat.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
