The role of Amyloid precursor protein (APP) in Alzheimer’s disease (AD)

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease, which endangered human life expectancy. Since 2020, approximately 50 million people worldwide had got AD. With the increase of longevity of the whole population, the potential threat of AD Also increase. Although the pathogeny of AD is still not entirely clear, there have developed several hypotheses for AD. One of them is Aβ hypothesis. It suggests the deposition of Aβ plaques outside the neuron cells. This may cause a series of problems. It may induce ER stress, oxidative stress, neuro-inflammation and inhabited LTP in patients’ hippocampus. These all stimulate the neuron cell death. The loss of neuron cells will further induce these symptoms and then triggered the loss of memory. Although there are still a lot of debates on the now existing drugs about AD, the further studies on the role of Aß on AD is needed.