The role of allelic variants of angiotensin-converting enzyme ACE and serotonin transporter SLC6A4 genes in cognitive dysfunction progression in patients with metabolic syndrome

Abstract

Background. Risk factors of cardiovascular diseases play an important role in the cognitive dysfunction (CD) progression. Objective. To determine allelic variants frequencies caused by ACE I/D ( rs4646994 ) polymorphism as well as the SLC6A4 L/S ( rs4795541 ) and A/G ( rs25531 ) polymorphisms in patients with different intensity of metabolic syndrome and CD. Design and methods. Fifty five participants underwent anthropometric measurements, blood tests (glucose, lipids), molecular genetic analysis (polymerase chain reaction, restriction fragments length polymorphism) and neuropsychological tests. Results. Allelic variant D of ACE gene as well as allelic variants S and L G of SLC6A4 gene are associated with metabolic syndrome progression. CD progression is associated with allelic variants S and L G of SLC6A4 gene, but not with allelic variants of ACE gene.