Abstract
1. The striatal neuronal response to dexamphetamine, 2.5 mg/kg, was studied in normal freely moving animals and in freely moving animals with unilateral lesions of the parafascicular-centromedian complex. 2. Whereas dexamphetamine produced predominantly excitation of striatal neurons in control animals, the predominant response in lesioned animals was inhibition. 3. In lesioned animals dexamphetamine-induced behavioral activation was unchanged. 4. It is concluded that the PF-CM complex plays an important role In the striatal neuronal response to dexamphetamine in freely moving animals and may be one of the neural substrates conveying sensory feedback from drug-Induced behavior to the striatum.
Published Version
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