The role of adiposity in endometrioid endometrial cancer

Abstract

The incidence of endometrial cancer (EC) is estimated to increase by 1–2% annually. More than half of all endometrioid EC diagnoses are currently attributable to obesity, which is an independent risk factor for this cancer. Multiple epidemiologic studies have demonstrated that obesity significantly increase the risk of several types of cancer, however, mechanisms by which obesity contribute to EC progression remain elusive. The objective of this study is to compare the effects of adiposity on endometrioid endometrial cancer cells in a paracrine, endocrine and intratumoral environment both invitro and in vivo.