Abstract
ABSTRACTAdiponectin, among other diverse adipokines, is produced in greater quantity and has an effect on the adipose tissue and other tissues in the body. Adiponectin plays three main roles: regulatory metabolic and sensitizing function of insulin in the liver and muscles; it acts as an anti-inflammatory cytokine and in vascular protection, besides important cardiac protection in the presence of ischemia-reperfusion syndrome. Since many situations resulting from traumatic accidents or pathologies are due to cell damage caused by ischemia-reperfusion syndrome, it is relevant to study new therapeutic alternatives that will contribute to reducing these lesions. The objective of this study is to carry out a literature review on the role of adiponectin in ischemia-reperfusion syndrome.
Highlights
❚❚DISCUSSION Adiponectin and ischemia-reperfusion syndrome in the heart muscle The pro-inflammatory states found in chronic diseases, especially those related to states of metabolic dysfunction, such as obesity and diabetes, are observable causes of hypoadiponectinemia
An important activation pathway of APN occurs through CP-3, an azapeptide from the class of selective CD36 binders, which leads to the activation of receptors activated by gamma peroxisome proliferator-activated receptors (PPARγ), one of the most important regulators of APN transcription
Caveolin acts as a potent signal inhibitor and suppressor of growth; some studies have suggested that, in the case of insulin, it acts as a facilitator for its action
Summary
Adiponectin (APN), among many other adipokines, is produced in greater quantities and has an effect on the adipose tissue and other tissues in the body. APN has three main roles: it regulates metabolism and insulin sensitivity in the liver and muscles; acts as an anti-inflammatory cytokine and in vascular protection; and has a cardioprotective effect in the presence of ischemia- reperfusion syndrome (IRS).(1,2,6-14). A significant number of articles have recently suggested the possible therapeutic uses of APN to reduce tissue damage caused by IRS in several organs. The exogenous use of this cytokine was able to reduce in vitro and in vivo apoptosis and necrosis in myocardial, brain, vascular, hepatic and renal tissues after IRS. The objective of this study is to conduct a literature review on the role of APN in IRS (Table 1)
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