Abstract
Adipose tissue is an endocrine organ secreting signal peptides adipokines. Adipokines play a significant role in the regulation of the immune, endocrine, nervous, excretory systems. Adipokine imbalance leads to chronic inflammation, metabolic and cardiovascular diseases. Obesity as the primary reason of the adipokine imbalance is the leading risk factor of hypertension, atherosclerosis and coronary artery disease. Thus, experimental and clinical studies of adipokine biology are essential for the development of the novel therapeutic approaches for the management of cardiometabolic diseases. This review focuses on the role of adiponectin, leptin, chemerin, omentin and visfatin in physiological and pathophysiological processes in the cardiovascular system.
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