Abstract
The role of adhesion molecules in nephropathies: The diagnostic applications
Highlights
Adhesion molecules refer to a diverse group of ligands/receptor molecules which facilitate cell adhesion either to other cells or to the extracellular matrix [1]
very late antigens (VLA)-4 which is expressed on lymphocytes, monocytes, basophils, and eosinophils plays the role of a receptor for both fibronectin and vascular cell adhesion molecule-1 (VCAM-1): a ligand of the immunoglobulin superfamily expressed on endothelial cells
In another study which evaluated VCAM-1 expression in renal biopsy specimens in patients with a variety of glomerulonephritides and tubulointerstitial diseases, this adhesion molecule was found to be natively expressed on renal tubular cells in those patients with vasculitis and crescentic nephritis, lupus nephritis, IgA nephropathy, and acute interstitial nephritis induced by non-steroidal anti-inflammatory drugs (NSAIDs) [29]
Summary
Adhesion molecules refer to a diverse group of ligands/receptor molecules which facilitate cell adhesion either to other cells or to the extracellular matrix [1]. The role of adhesion molecules in renal diseases (especially nephropathies) and their diagnostic applications as biomarkers are discussed.
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