Abstract
Preeclampsia is a complex disease that increases both maternal and fetal morbidity and mortality in both developed and developing countries. It complicates around 5-10% of all pregnancies..The pathophysiology of preeclampsia includes both maternal and fetal/placental factors. Implantation of embryo and placentation are crucial steps for development of pregnancy involving trophoblast invasion. Abnormalities of spiral artery invasion, trophoblast function, inflammatory process, and biologic functions of angiogenic/anti-angiogenic factors early in pregnancy result in pregnancy diseases, including preeclampsia. ADAMTS genes are members of the family of matrix metalloproteinase, which have important tasks in extracellular matrix (ECM) degradation and repair processes. The roles of ADAMTS in preeclampsia may include regulation of spiral artery invasion and ECM arrangement of the placenta.
Highlights
Preeclampsia is a complex disease that increases both maternal and fetal morbidity and mortality in both developed and developing countries. It complicates around 5-10% of all pregnancies..The pathophysiology of preeclampsia includes both maternal and fetal/placental factors
Preeclampsia is defined as the clinical condition associated with hypertension and proteinuria or end-organ dysfunction in a woman who was normotensive before 20 weeks gestation[1,2]
According to data in the United States in 2010, 12% of pregnancy-associated maternal deaths are due to preeclampsia and eclampsia[1]
Summary
©Turkish Journal of Obstetrics and Gynecology, Published by Galenos Publishing House. ADAMTS degrade molecules that act on regulation of the tissue microenvironment Some of these molecules belong to the ECM (collagen, proteoglycan, and many other glycoproteins), and others do not (receptors, growth factors, and cytokines). ADAMTS should be expressed, and the ECM must be degraded and formed so that trophoblasts can invade maternal tissues and spiral arteries. Deficiency of ADAMTS-12 may cause defective trophoblast differentiation, abnormal remodeling of spiral arteries, and abnormal development of the placenta, which induces preeclampsia. ADAMTS genes are associated with other diseases such as ovarian cancer, polycystic ovarian syndrome, and premature ovarian failure[36,37] These genes play multiple roles in male and female fertility[38]
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