Abstract
BackgroundThe prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. In this study, we analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabolism.MethodsWe retrospectively analyzed the factors that affect the blood lipid level in 717 tumor-free healthy adults who received blood lipid measurement and PET/CT scan by multivariate regression analysis. We also determined the role of aBAT on lipid profile by case–control study.Results(1) Our results showed that 411 (57.3 %) subjects had dyslipidemia. The prevalence of the subjects with hypercholesteremia, hypertriglyceridemia, low high-density lipoprotein cholesterol and high low-density lipoprotein cholesterol was 9.5 %, 44.4 %, 30.8 % and 1.4 %, respectively. Multivariate logistic regression analysis with dyslipidemia as the dependent variable showed that body mass index (BMI) and smoking are independent risk factors for dyslipidemia (OR > 1, P < 0.05), while the presence of aBAT is the independent protective factor for dyslipidemia (OR < 1, P < 0.05). (2) The incidence of aBAT was 1.81 %. Subjects with aBAT had significantly lower serum triglyceride and higher serum high-density lipoprotein cholesterol than the subjects without aBAT. The serum total cholesterol and low-density lipoprotein cholesterol were not significantly different between the subjects with aBAT and those without aBAT.ConclusionsDyslipidemia is caused by multiple factors and the presence of aBAT is a protective factor for dyslipidemia in healthy Chinese adults.
Highlights
The prevalence of dyslipidemia in China was increased over the last several years
Dyslipidemia is caused by multiple factors and the presence of active brown adipose tissue (aBAT) is a protective factor for dyslipidemia in healthy Chinese adults
The statistically significant factors in univariate analysis were further analyzed by multivariate logistic regression analysis. These results showed that high body mass index (BMI) and smoking were independent risk factors for dyslipidemia (OR > 1, P < 0.05), and the presence of aBAT was an independent protective factor for dyslipidemia (OR < 1, P < 0.05) (Table 3)
Summary
The prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. We analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabolism. Dyslipidemia is a major risk factor for atherosclerosis. Dyslipidemia is the independent risk factor for myocardial infarction [3] and ischemic stroke [4], and represents a serious threat to human health. Brown adipose tissue (BAT) is the main source of non-trembling heat, and it plays an important role in maintaining the body temperature and energy metabolism balance. Shao et al Lipids in Health and Disease (2016) 15:138 The mitochondrial inner membrane of brown fat cells is rich in uncoupling protein 1 (UCP l), which converts chemical energy into thermal energy through the uncoupling of oxidative phosphorylation [6].
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