Abstract
Myofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expression, is a key process in organ fibrosis. Our recent studies have shown that AcSDKP has a anti-fibrotic effect in the lung of rats with silicosis. Here we explore the underlying effect of AcSDKP on myofibroblast differentiation during the anti-fibrotic process. SiO 2 powders were instilled in trachea of rat to make the silicotic model, and caused 1) increased expressions of TGF-β, 2) escalated serum response factor (SRF) expression, 3) myofibroblast marked by o-SMA being detected in siliconic nodules, and 4) collagen deposition in lung. AcSDKP (both anti fibronic and prevention treatment) can inhibit these changes induced by silica significantly. AcSDKP could inhibit collagen synthesis throuth blocking myofibroblast differentiation in the lung of rats with silicosis, which is a new mechanism of its anti-silicotic effect.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
