Abstract
Acetyl-CoA carboxylase(ACC) is a speed limit enzyme of fatty acid synthesis. It catalyzes acetyl-CoA to generate malony CoA, which is the precusor of the long chain fatty acid. Furthermore, malony CoA can not only provide donor for fatty acid synthesis, but also as an allosteric inhibitor of fatty acid transport into mitochondria for oxidation. Therefore, ACC plays an vital role in fatty acid synthesis and metabolism. Because of its special biological functions, ACC plays an increasingly important role in obesity, nonalcoholic fatty liver disease, diabetes, hyperuricemia and can be a potential therapeutic target of metabolic diseases. Key words: Acetyl-CoA carboxylase; Fatty acid synthesis; Endocrinal and metabolic diseases
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