Abstract
A high proportion of neurones in the intracerebellar nuclei (ICN) of the cat are excited by acetylcholine (ACh) applied by iontophoresis. Experiments were carried out to characterize the receptors involved and to attempt to relate the findings to synaptic transmission in the ICN. Excitation followed the iontophoretic application of cholinomimetics, without a clear-cut separation into those with nicotine actions and those with muscarine actions. Experiments using atropine and dihydro-β-erythroidine indicated that both muscarinic and nicotine receptors are likely to be present. The activation induced by stimulation of 4 different afferent pathways was found to be qualitatively similar. Iontophoretically applied atropine did not appear to alter the responses: it seems likely that no excitatory pathways using muscarinic receptors are operating in the ICN of decerebrated cats.
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