Abstract
There is considerable evidence supporting the involvement of serotonin-2C (5-HT2C) receptors in the pathophysiology of depression. First, 5-HT2C receptors play an important role in the regulation of monoamine transmission. Second, abnormalities in expression and functioning of 5-HT2C receptors have been observed in depressed patients and in animal models of depression. Third, a large body of evidence indicates that 5-HT2C receptors mediate certain behavioral functions that are disturbed in depression. Finally, some compounds acting on 5-HT2C receptors are effective in the treatment of depression. This chapter aims to summarize these four lines of evidence for the involvement of 5-HT2C receptors in pathophysiology and treatment of depression.
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