Abstract
Cannabinoidergic as well as serotonergic systems of the amygdala modulates anxiety like behaviors and emotional memory. The effects of cannabinergic system on the anxiety and learning process relate to the central amygdala and its interaction with serotonergic system have not studied yet. With the aim of evaluating the regulating effects of cerotonergic system on the anxiolytic effects of cannabinoids and the possibility of restoring cannabinoid caused amnesia by certonergic system, the current research was conducted using the elevated plusmaze (EPM) test-retest paradigm in the male mice. The bilateral guide-cannulae were implanted to allow intraCeA microinjection of serotonergic agents. The formation of emotional memory was declined by intra-CeA injection of ACPA, but the anxiety reaction was not affected by the various doses of the mentioned substance. Intra-CeA injection of CP94253 Hydrocholoride, a 5-HT1 serotonin receptor agonist, diminished the formation of emotional memory and the locomotor activity, while 5-HT1 serotonin receptor antagonist, did not influence the anxiety-like behaviors and the emotional memory formation. According to the obtained findings from the current research, it seems that ACPA may trigger anxiolytic-like behaviors and prevent the emotional memory formation, mainly via the activation and deactivation of the CeA 5-HT1 serotonin receptors.
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