Abstract
Fifty five Khakas people with Helicobacter pylori-associated ulcer disease and chronic gastritis were examined in order to estimate the production of IL-2, IL-4, and IL-10 interleukins in patients with chronic Helicobacter pylori persistence. The subpopulation composition of lymphocytes of peripheral blood was determined by the method of flow-through cytofluorometry. Apoptosis was estimated by the method of optical microscopy. The IL-2, IL-4, IL-10 production in supernatants was determined by the solidphase immunoenzymometric method. Changes revealed in the blood of patients infected with Helicobacter pylori were characterized by the increased amount and subpopulation disbalance of lymphocytes, apoptosis modification, and depletion of lymphocyte functional activity.
Highlights
Обследовано 55 хакасов с Helicobacter pylori-ассоциированными язвенной болезнью и хроническим гастритом
Fifty five Khakas people with Helicobacter pylori-associated ulcer disease and chronic gastritis were examined in order to estimate the production of IL-2, IL-4, and IL-10 interleukins in patients with chronic Helicobacter pylori persistence
The subpopulation composition of lymphocytes of peripheral blood was determined by the method of flow-through cytofluorometry
Summary
Роль нарушений системы цитокинов в патогенезе Helicobacter pylori-ассоциированной патологии. Целью работы являлось оценить продукцию интерлейкинов IL-2, IL-4, IL-10 у пациентов с хронической персистенцией Helicobacter pylori. Субпопуляционный состав лимфоцитов периферической крови определяли методом проточной цитофлюориметрии. Ключевые слова: Helicobacter pylori, язвенная болезнь, хакасы, апоптоз, иммунный ответ, лимфоциты. The subpopulation composition of lymphocytes of peripheral blood was determined by the method of flow-through cytofluorometry. Changes revealed in the blood of patients infected with Helicobacter pylori were characterized by the increased amount and subpopulation disbalance of lymphocytes, apoptosis modification, and depletion of lymphocyte functional activity. Учитывая важную роль дисрегуляции Th1/Th2системы в патогенезе хронического инфекционного процесса, целью настоящего исследования явилась оценка продукции IL-2, IL-4 и IL-10 лимфоцитами крови у пациентов с H. pylori-ассоциированной патологией
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