The Role and Prevalence of Polyol Pathway and Oxidative Stress Markers as Risk Factors for Diabetic Cataract in Adult Type-I Diabetic and Diabetic Cataract Saudi Patients

Fahad Alwadani,Musad Saif

doi:10.4172/2155-9570.1000558

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia and its prevalence is rising globally. Prolonged exposure to uncontrolled chronic hyperglycemia can lead to various complications in the eye including cataract. Cataract is characterized by cloudiness or opacification of the eye lens which is the leading cause of sight loss and visual disability. It has been reported that diabetes mellitus is a major problem in the management of blindness and cataract surgery.

Highlights

In recent years, various studies suggested that oxidative stress may play a role in the pathogenesis of both type 1 and type 2 Diabetes mellitus (DM) and its impact on lens transparency [1,2,3,4,5]
Various studies reported that the persistent hyperglycemia in both types of diabetic patients produces excess ROS leading to increased oxidative protein damage and lipid peroxidation, which would be related to the pathogenesis of diabetic’s complications including cataract [9,10,11]
Age and gender distribution and body mass index showed no significant difference between the various groups

Summary

Introduction

Various studies suggested that oxidative stress may play a role in the pathogenesis of both type 1 and type 2 DM and its impact on lens transparency [1,2,3,4,5]. Various studies reported that the persistent hyperglycemia in both types of diabetic patients produces excess ROS leading to increased oxidative protein damage and lipid peroxidation, which would be related to the pathogenesis of diabetic’s complications including cataract [9,10,11]. A number of studies have evaluated the oxidant markers in diabetes and its complications but with inconsistent results. While some studies reported increased MDA, a marker of lipid peroxidation and lowered activities of SOD, CAT and GSH-Px in patients of DM [10,11,12,13], others have reported no change in indices of oxidative stress [14,15,16]

Methods

Results

Conclusion