Abstract
The P2Y receptor family is a class of G protein-coupled receptors activated primarily by adenosine triphosphate (ATP), adenosine diphosphate (ADP), uridine triphosphate (UTP) and uridine diphosphate (UDP). The P2Y12 receptor is expressed on platelets which mediates platelet aggregation and morphological changes. At the same time, during the process of vascular remodeling and atherosclerosis, ADP can also promote the migration and proliferation of vascular smooth muscle and endothelial cells through P2Y12 receptor activating. Furthermore, P2Y12 is involved in many signal transductions processes, such as intimal hyperplasia, monocyte infiltration and so on, which play an important role in immune inflammation and brain injury. In order to solve the diseases induced by P2Y12 receptor, inhibitors such as ticagrelor, clopidogrel were widely used for cardiovascular diseases. However, there were some problems, such as limited antithrombotic effect, remain unsolved. This article summarizes the role and molecular mechanism of P2Y12 receptors in the pathogenesis of cardiovascular-related diseases, providing in-depth expounding on the molecular mechanism of P2Y12 receptor inhibitors and contributing to the treatment of diseases based on P2Y12 receptors.
Highlights
The P2Y receptor family is a class of G protein-coupled receptors (GPCRs) activated mainly by adenosine triphosphate (ATP), adenosine diphosphate (ADP), uridine triphosphate (UTP) and uridine diphosphate (UDP)
Ticagrelor promotes a greater inhibition of adenosine 50 -diphosphate (ADP)-induced Ca2+ release in shed platelets compared with other P2Y12R antagonists
We summarized the related signal transduction processes of P2Y12 receptors that participate in the physiological and pathological processes of diseases in various ways
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The P2Y receptor family is a class of G protein-coupled receptors (GPCRs) activated mainly by ATP, ADP, UTP and UDP. They are widely distributed in humans and are closely related to several physiological functions. The receptor gene is located in human chromosome 3q25.1 [4]. P2Y12 receptor was found on vascular smooth muscle, microglia, dendritic cells, macrophages and lymphocytes, which played an important role in guiding cells to a specific area [5,6]. The P2Y12 receptor plays an important role in various diseases such as thrombus myocardial atherosclerosis, brain injury repair process, and so on [7,8]. This article summarizes the role and mechanism of P2Y12 receptor-associated cardiovascular disease, explores the key role of P2Y12 receptor in the development of the disease further and provides new ideas for the combined clinical use of P2Y12 inhibitor drugs and drug conversion [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
