Abstract
Drosophila melanogaster sbr (small bristles) is an orthologue of the Nxf1 (nuclear export factor 1) genes in different Opisthokonta. The known function of Nxf1 genes is the export of various mRNAs from the nucleus to the cytoplasm. The cytoplasmic localization of the SBR protein indicates that the nuclear export function is not the only function of this gene in Drosophila. RNA-binding protein SBR enriches the nucleus and cytoplasm of specific neurons and glial cells. In sbr12 mutant males, the disturbance of medulla boundaries correlates with the defects of photoreceptor axons pathfinding, axon bundle individualization, and developmental neurodegeneration. RNA-binding protein SBR participates in processes allowing axons to reach and identify their targets.
Highlights
Enriches the nucleus and cytoplasm of specific neurons and glial cells
The best known function of the Nxf1 genes is the transport of various mRNAs from the nucleus to the cytoplasm [1]
NXF1 is localized in the nucleus or the nuclear envelope according to its function [4]
Summary
Enriches the nucleus and cytoplasm of specific neurons and glial cells. In sbr mutant males, the disturbance of medulla boundaries correlates with the defects of photoreceptor axons pathfinding, axon bundle individualization, and developmental neurodegeneration. As we have shown previously, D. melanogaster SBR (Dm NXF1) is located in the nucleus and in the cytoplasm of different cells [5,6,7]. This finding suggests that the SBR protein has specific cytoplasmic functions in addition to its participation in nuclear export of mRNAs. In the Drosophila larval brain, SBR forms granules in the neuron bodies and neurites [7]. Others are marked by either FMR1 or SBR These observations suggest that SBR has specific localized RNA targets in the cytoplasm [8].
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