Abstract
The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found that aberrant expression and dysregulated function of RBM proteins family members are closely related to the occurrence and development of cancers. This review summarizes the role of RBM proteins family genes in cancers, including their roles in cancer occurrence and cell proliferation, migration, and apoptosis. It is essential to understand the mechanisms of these proteins in tumorigenesis and development, and to identify new therapeutic targets and prognostic markers.
Highlights
RNA-binding proteins (RBPs) are a kind of crucial intracellular protein, which can be widely involved in a variety of post-transcriptional regulation processes, such as RNA splicing, transport, localization, and translation
RBPs are divided into many kinds according to different functions, including Hu-antigen R (HuR), heterogeneous nuclear ribonucleoprotein family, the arginine/serine-rich splicing factor protein family (SRSF), and RNA-binding motif (RBM) proteins family, etc
The results showed that members of the RBM proteins family were significantly correlated with tumor prognosis, and the expression levels of many RBM members could predict the prognosis of tumor patients (Figure 2)
Summary
RNA-binding proteins (RBPs) are a kind of crucial intracellular protein, which can be widely involved in a variety of post-transcriptional regulation processes, such as RNA splicing, transport, localization, and translation. RBM Proteins Family Can Promote Tumor Cell Proliferation Studies have found that RBM proteins family can promote the proliferation of tumor cells. RBM Proteins Family Inhibits Tumor Cell Proliferation
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