The risk of malignancies in women with long flowing hyperthyroidism in history: a retrospective randomized study

Abstract

The syndrome of thyrotoxicosis is the second occurrence in endocrine diseases giving way to the only diabetes. The most common cause of hyperthyroidism is Graves' disease. Nodular toxic goiter is following Graves' disease. Then more rare causes are solitary toxic adenoma and thyroiditis. Epidemiological studies carried out at the turn of XX-XXI centuries in the developed countries of Europe and North America have shown that a history of hyperthyroidism episode increases the relative risk of development of ovarian cancer by 80 % and breast cancer by 45-60 %. It has been shown that hyperthyroidism including subclinical one is a risk factor for morbidity and mortality from malignant neoplasms of different localizations as breast cancer, thyroid cancer, pancreatic cancer and lung cancer. In this case, drew the fact that significant differences in the risk of morbidity by specific disease forms depends on the ethnic composition of the population. In Russian Federation the similar epidemiological studies have not been carried out yet. We obtained the results of an epidemiological retrospective multicenter randomized clinical simultaneous analytical comparative study of the “case-control” among women treated for diffuse toxic goiter and nodular toxic goiter in 1999-2009. The study involved 1135 patients with hyperthyroidism in anamnesis. The comparison group included 953 patients with eu- and hyperthyroid status. The risk of malignancies in women with hyperthyroidism in anamnesis was 2.36 (95 % CI 1.63-3.42, p < 0.01). The risk of hormone-dependent tumors was 2.65 ( 95 % CI 1.7-4.13, p < 0.01). The aim: to evaluate the risk of malignancies in women with long flowing hyperthyroidism.