Abstract
BackgroundWhether herpes zoster infection (HZI) affects laryngitis incidence remains unknown.ObjectiveThe purpose of this population-based retrospective study was to analyze the relationship between laryngitis and HZI using data from the Korean Health Insurance Review and Assessment Service—National Sample Cohort.MethodsThis study analyzed 1,197,093 medical claim codes from 2018. Patients with HZI (ICD-10: B02) were retrospectively identified. Laryngeal diseases were defined by ICD-10 codes for five subgroups: 1) malignant disease, 2) benign disease, 3) vocal cord palsy, 4) inflammatory disease, and 5) reflux disease.ResultsAmong the Korean population older than 20 years, 12,809 experienced HZI. Subjects with HZI were more likely to be older (mean age: 51.54 years vs. 48.06 years, p <0.0001). The proportion of subjects with laryngeal disease was higher in those with HZI than in those without HZI (55.55% vs. 41.37%, p <0.0001). Laryngeal disease was significantly associated with HZI in multiple regression analysis (odds ratio (OR) = 1.77, 95% confidence interval: 1.71–1.84) after adjusting for age, sex, hypertension, diabetes, dyslipidemia, ischemic heart disease, cerebral stroke, and depression. Among laryngeal disease subgroups, inflammatory disease (OR = 1.05; 95% CI: 1.01–1.09) and reflux (OR = 1.20; 95% CI: 1.15–1.25) were associated with HZI.ConclusionsHZI is independently associated with laryngitis. Results of this study have implications for etiological investigations and prevention strategies for laryngitis.
Highlights
Laryngeal disease was significantly associated with herpes zoster infection (HZI) in multiple regression analysis (odds ratio (OR) = 1.77, 95% confidence interval: 1.71–1.84) after adjusting for age, sex, hypertension, diabetes, dyslipidemia, ischemic heart disease, cerebral stroke, and depression
Inflammatory disease (OR = 1.05; 95% confidence interval (CI): 1.01–1.09) and reflux (OR = 1.20; 95% CI: 1.15–1.25) were associated with HZI
Herpes zoster laryngitis is a rare manifestation of herpes zoster infection (HZI), which is widely described in case reports
Summary
Herpes zoster laryngitis is a rare manifestation of herpes zoster infection (HZI), which is widely described in case reports. In South Korea in 2015, there were 469,268 HZI cases, and the prevalence was 9.22/1000 person-years [2]. Laryngitis occurs when the larynx become inflamed, swollen, and irritated. Acute laryngitis is inflammation of the vocal fold mucosa and larynx that lasts less than three weeks [3, 4]. Chronic laryngitis is diagnosed when signs and symptoms last longer than three weeks and can have infectious or non-infectious causes [4,5,6]. In Korea, the prevalence of chronic laryngitis was 3.8±0.7% [7]. Whether herpes zoster infection (HZI) affects laryngitis incidence remains unknown
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