Abstract
Objective: to estimate the high and very high Frax® 10-year probabilities of fractures in patients with systemic sclerosis (SSc) to assess the need for anti-osteoporotic treatment.Patients and methods. The investigation enrolled 136 SSc patients (110 women and 26 men; mean age, 59.3±7.5 years). The patients underwent a questionnaire survey, by calculating the risk of major fractures with the FRAX® algorithm and dual-energy X-ray densitometry (DXA) of the lumbar spine and proximal femur.Results and discussion. There was a very high risk of fractures in 41.2% of the examinees, a high risk in 10.3%, and a low risk in 48.5%. Osteoporosis (OP) in at least one area was detected in 41.2% of the patients. Among the persons with a low risk of fractures, OP was diagnosed in 18.2%, whereas 10.6% had a history of fractures. A total of 65.4% of SSc patients needed anti-osteoporotic treatment.Conclusion. According to the comprehensive assessment, OP treatment and fracture prevention were indicated for 65.4% of SSc patients. The FRAX® algorithm is less informative in males who need therapy than in females.
Highlights
Objective: to estimate the high and very high Frax® 10-year probabilities of fractures in patients with systemic sclerosis (SSc) to assess the need for anti-osteoporotic treatment
There was a very high risk of fractures in 41.2% of the examinees, a high risk in 10.3%, and a low risk in 48.5%
Osteoporosis (OP) in at least one area was detected in 41.2% of the patients
Summary
2. Риск основных остеопоротических переломов по FRAX® с включением показателя Т-критерия ШБ Fig. 2. The risk of major osteoporotic fractures by FRAX® with inclusion of femoral neck T-scores ледующем все больные были разделены на группы очень высокого, высокого или низкого риска Оценка 10-летнего риска основных остеопоротических переломов по FRAX® с использованием графика, представленного на рис. Умеренного или низкого 10-летнего риска основных остеопоротических переломов по FRAX® у больных ССД, n (%) Table 2. Moderate, or low Frax® 10-year probabilities of major osteoporotic fractures in SSc patients, n (%). Высокого и очень высокого 10-летнего риска основных остеопоротических переломов по FRAX® у больных ССД с учетом показателя Т-критерия ШБ, n (%) Table 3. High, and very high Frax® 10-year probabilities of major osteoporotic fractures in SSc patients in terms of femoral neck T-scores, n (%). Frequency of OP in SSc patients according to DXA, n (%)
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