The risk of Creutzfeldt–Jakob disease infection in cadaveric surgical training

Abstract

The usefulness of cadaver surgical training in the clinical field is already well known. In Japan, the number of universities introducing cadaver surgical training is increasing. In addition to formalin fixation, various fixation methods are used, such as the Thiel method, saturated salt solution method, N-vinyl-2-pyrrolidone method, and fresh-frozen cadavers. Although protection against infections during fixation and cadaver surgical training has been implemented in most universities, it is currently inadequate. Furthermore, the possibility of undiagnosed infectious diseases in donors cannot be excluded. Prion diseases, such as Creutzfeldt-Jakob disease, are relatively rare, but they are fatal, with no effective treatment. The abnormal prion protein that causes prion diseases is resistant to formaldehyde and cannot be inactivated by all methods of cadaver fixation presently in use. Recently developed real-time quaking-induced conversion has been reported to be a useful screening method for prion infection. In addition, this article aims to raise awareness of prion diseases in cadaver surgical training by reviewing the current understanding of prion diseases in cadavers and their screening methods.