Abstract
BackgroundPsoriasis is a chronic systemic inflammatory disorder, and studies have revealed its association with a variety of comorbidities. However, the risk of chronic pancreatitis (CP) in psoriasis has not been studied. This study aimed to investigate the risk of CP among patients with psoriasis.MethodsUsing the Taiwan National Health Insurance Research Database, this population-based cohort study enrolled 48430 patients with psoriasis and 193720 subjects without psoriasis. Stratified Cox proportional hazards models were used to compare the risks of CP between the patients with and without psoriasis.ResultsThe incidence of CP was 0.61 per 1000 person-years in patients with psoriasis and 0.34 per 1000 person-years in controls during a mean 6.6-year follow-up period. Before adjustment, patients with psoriasis had a significantly higher risk of CP (crude hazard ratio (HR) = 1.81; 95% confidence interval (CI) = 1.53–2.15), and the risk remained significantly higher after adjustments for gender, age group, medications, and comorbidities (adjusted HR (aHR) = 1.76; 95% CI = 1.47–2.10). All psoriasis patient subgroups other than those with arthritis, including those with mild and severe psoriasis and those without arthritis, had significantly increased aHRs for CP, and the risk increased with increasing psoriasis severity. Psoriasis patients taking nonsteroidal anti-inflammatory drugs (aHR = 0.33; 95% CI = 0.22–0.49) and methotrexate (aHR = 0.28; 95% CI = 0.12–0.64) had a lower risk of developing CP after adjustments.ConclusionsPsoriasis is associated with a significantly increased risk of CP. The results of our study call for more research to provide additional insight into the relationship between psoriasis and CP.
Highlights
Patients with psoriasis had a significantly higher risk of chronic pancreatitis (CP) (crude hazard ratio (HR) = 1.81; 95% confidence interval (CI) = 1.53–2.15), and the risk remained significantly higher after adjustments for gender, age group, medications, and comorbidities (adjusted HR = 1.76; 95% CI = 1.47–2.10)
All psoriasis patient subgroups other than those with arthritis, including those with mild and severe psoriasis and those without arthritis, had significantly increased adjusted hazard ratio (aHR) for CP, and the risk increased with increasing psoriasis severity
Psoriasis patients taking nonsteroidal anti-inflammatory drugs and methotrexate had a lower risk of developing CP after adjustments
Summary
A chronic inflammatory T-cell-mediated disease, affects 2–3% of the general population and was considered a disease limited to the skin and joints.[1,2,3,4] Recent research has emphasized that psoriasis is a multisystemic disease associated with a variety of comorbidities, such as cardiovascular disease, diabetes, and chronic renal diseases.[5,6,7,8,9,10] only few small studies or case reports have been published regarding the pancreas dysfunction or acute pancreatitis in psoriasis.[11,12,13] And the study investigating the risk of chronic pancreatitis (CP) in psoriasis is lacking.CP, an irreversible inflammatory disease of the pancreas, is characterized by chronic inflammatory cell infiltration and acinar cell degeneration, leading to progressive destruction of exocrine and endocrine tissue and fibrosis.[14]. A chronic inflammatory T-cell-mediated disease, affects 2–3% of the general population and was considered a disease limited to the skin and joints.[1,2,3,4] Recent research has emphasized that psoriasis is a multisystemic disease associated with a variety of comorbidities, such as cardiovascular disease, diabetes, and chronic renal diseases.[5,6,7,8,9,10] only few small studies or case reports have been published regarding the pancreas dysfunction or acute pancreatitis in psoriasis.[11,12,13] And the study investigating the risk of chronic pancreatitis (CP) in psoriasis is lacking. Psoriasis is a chronic systemic inflammatory disorder, and studies have revealed its association with a variety of comorbidities. The risk of chronic pancreatitis (CP) in psoriasis has not been studied. This study aimed to investigate the risk of CP among patients with psoriasis
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