The risk of cardiovascular events in persons with a non-cardiac pathology

O V Khlynova ,Liubov Vasilets ,Ekaterina Shishkina ,А В Туев ,С В Наумов ,Grigoriy Spasenkov ,Татьяна Павловна Калашникова

doi:10.7324/japs.2017.70730

Abstract

Nowadays, one of the main areas in internal disease treatment is preventive medicine, which includes the risk measurement method. This method is often used in cardiology to assess both the possibilities of disease emergence and its progression or complicated course. The purpose of this study was to investigate the possibilities of identifying factors of cardiovascular risks in people with GERD and obesity. Eighty patients, whose average age was 47.1±5.5, were examined. The results of the study allowed distinguishing prognostic factors of cardiovascular risks for persons with isolated forms of GERD and obesity, as well as their comorbidity. The developed formulas and models allow assessing the risk of cardiovascular diseases individually for obesity, gastroesophageal reflux disease, and the combination thereof. We determined the risk of cardiovascular diseases in cases of obesity and in GERD patients, which is a result of the features of chronobiologic indicators of the organism, the metabolic profile, and the degree of deleterious lesions of the esophageal mucosa in patients. The presented model characterizes the probability of emergence of cardiovascular diseases in patients with non-cardiac pathologies. This study can be used to design new methods of prevention of cardiovascular events.

Highlights

The incidence of gastroesophageal reflux disease and obesity has been on the rise all over the world over the past several decades (Camilleri, 2005; Nandurkar, 2006; Kachina, 2013)
We determined the risk of cardiovascular diseases in obese people and gastroesophageal reflux disease patients, which results from the features of the chronobiologic indicators of the organism, the metabolic profile, and the degree of deleterious lesions of the esophageal mucosa in patients
It has been proven that patients with combined gastroesophageal reflux disease and obesity often have apnea episodes in their sleep, systemic inflammation associated with obesity, which emerges when the level of circulating cytokines increases, oxidative stress, and hormone secretion disorders, which exacerbate the pathogenic mechanisms of formation and progression of both gastroesophageal reflux disease and obesity (Camilleri, 2005; Khlynova, 2012; Vasilets, 2014).These factors can increase the risk of cardiovascular diseases in persons with an associated course of gastroesophageal reflux disease and obesity

Summary

Introduction

The incidence of gastroesophageal reflux disease and obesity has been on the rise all over the world over the past several decades (Camilleri, 2005; Nandurkar, 2006; Kachina, 2013). When studying the association of gastroesophageal reflux disease and obesity, it is necessary to take into consideration the fact that both diseases develop in persons that have problems with nutrition and lifestyle, as well as a genetic predisposition to such diseases (Jones, 2005; Tkach, 2007). Various studies have confirmed the existence of a certain correlation between the exacerbation of gastroesophageal reflux disease and body weight gain in humans. These studies have noted that an increase in alcohol consumption and smoking abuse could cause obesity (Hampel et al, 2005)

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