The Risk Factors of Anastomotic Leakage After Rectal Cancer Surgery

Abstract

Background: Anastomotic leakage is a significant complication after colorectal anastomosis. The aim of this study was to evaluate the risk factors and preventive measures for anastomotic leakage after rectal cancer surgery. Methods: A total of 171 patients who had undergone laparoscopic and open rectal cancer resection with a double stapling participated in this study. Twelve independent variables include age, sex, obesity, smoking, ASA grading, medical diseases, preoperative radiotherapy, preoperative chemotherapy, splenic flexure mobilization, diverting ileostomy, and the number of stapler firing were analyzed. Results: The anastomotic leakage rate was 2.33% (4 of 171). The mean age of the patients was 58.33 years old while their mean body mass index (BMI) was calculated as 24.10 kg/m2. In our study, 16.3% of patients were cigarette smokers. Of the 171 rectal surgeries, 69.0% of patients were diverted by loop ileostomy and 1.16% were supported by ghost ileostomy. Of 171 patients included in this study, 17.5 % of patients required a single staple firing for rectal division. In contrast, 47.9% of patients required 2 linear staplers, others, 24.5% of patients required 3 cartridges for rectal division, and 9.9% of patients required 4 cartridges in their surgeries. There were significant differences between men and women in the number of cartridges used (P = 0.023). Conclusions: All our leakage cases were men and the higher number of stapler firings for rectal division, history of smoking; male gender, and level of anastomosis were independent risk factors for the anastomotic leak.